Cancer Immunology at the Crossroads: Experimental Immunotherapies T-cell–based Immunotherapy: Adoptive Cell Transfer and Checkpoint Inhibition

Tumor immunotherapy has had demonstrable efficacy in patients with cancer. The most promising results have been with T-cell–based therapies. These include adoptive cell transfer of tumor-infiltrating lymphocytes, genetically engineered T cells, and immune checkpoint inhibitor antibodies. In this review, we describe the different T-cell–based strategies currently in clinical trials and put their applications, present and future, into perspective. Cancer Immunol Res; 3(10); 1115–22. 2015 AACR.